Congresso Brasileiro de Microbiologia 2023

Congresso Brasileiro de Microbiologia 2023

Resumo: 1085-1

1085-1

IMPREGNATION OF IMIDAZOLIUM SALTS IN FABRICS AND NON-WOVEN FABRICS FOR USE AS INPUT IN THE MAKING OF INDIVIDUAL AND COLLECTIVE PROTECTION EQUIPMENT AIMING AT THE PREVENTION OF INFECTIONS BY RESISTANT MICROORGANISMS

Autores:

Henri Stephan Schrekker (UFRGS - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL) ; Clarissa Martins Leal Schrekker (UFRGS - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL) ; Michele Oliveira Vieira (UFRGS - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL) ; Igor Luiz Gonçalves Pereira (UFRGS - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL) ; Stéfano Caon Tallamini (UNISUL - UNIVERSIDADE DO SUL DE SANTA CATARINA) ; Karine Modolon Zepon (UNISUL - UNIVERSIDADE DO SUL DE SANTA CATARINA)

Resumo:

According to the World Health Organization, generalized infection is the main cause of death within intensive care units and one of the main causes of late hospital death, surpassing myocardial infarction and cancer. Infections by bacteria, fungi, viruses and protozoan that are difficult to treat are becoming increasingly frequent in hospital environments, which allows, for example, colonization and infection by Candida sp. Such yeasts have been developing mechanisms of resistance to classic antifungals. Another aggravating factor in this scenario is the fact that microorganisms are capable of surviving for minutes or even months on surfaces. This survival condition is one of the main factors that favor the transmission of microorganisms. Multidrug resistance to traditional antimicrobials represents a worldwide public health problem. Urgent measures are needed to improve this situation. Within this context, the class of imidazolium salts (IS) is highly promising due to their activity against bacteria, fungi, protozoan and viruses. Understanding that occupational exposure is currently considered one of the main routes of transmission of microorganisms with antimicrobial resistance and antimicrobial textiles have proved to be a promising biosafety strategy, the antimicrobial action of IS justifies the objective of this work. Thus, this study focused on identifying the potential use of cotton-based and polyester-based nonwoven fabrics impregnated with IS for use as an input in the manufacture of individual (PPE) and collective (CPE) protective equipment to be used in environments with a high risk of transmission. The synthesis of IS was carried out following literature procedures and the characterization of the products was performed by 1H and 13C NMR spectroscopy. The evaluation of the antimicrobial activity of fabric samples followed the AATCC 100-2004 methodology (Assessment of Antibacterial Finishes on Textile Materials), with minor modifications. All IS were obtained in high yields and in pure form. The impregnation of IS in cotton-based and polyester-based nonwoven fabrics showed excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus and Candida albicans. More specifically, for both fabric samples, the impregnation of IS zeroed the load of E. coli and S. aureus and was able to reduce 10⁵ log units of Candida albicans. Thus, these fabrics impregnated with IS are promising materials for biosafety strategies.

Palavras-chave:

Personal and collective protective equip, Imidazolium salt, Textile substrates, Antimicrobial resistant microorganisms, Impregnation

Agência de fomento:

National Council for Scientific and Technological Development – CNPq and Ministry of Science, Technology and Innovations – MCTI (Process 408894/2022-9)